![]() During March 29–July 10, 2022, approximately 16.8 million persons in the United States aged ≥50 years received a fourth dose. ![]() passive surveillance system for monitoring adverse events after vaccination, managed by CDC and FDA ( 3). active surveillance system that monitors adverse events occurring after COVID-19 vaccination. V-safe is a voluntary smartphone-based U.S. To characterize the safety of a second mRNA booster dose among persons aged ≥50 years, CDC reviewed adverse events and health impact assessments reported to v-safe and the Vaccine Adverse Event Reporting System (VAERS) after receipt of a second mRNA booster dose during March 29–July 10, 2022. The Advisory Committee on Immunization Practices (ACIP) recommends that all persons aged ≥5 years receive 1 booster dose of a COVID-19 vaccine after completion of their primary series.* On March 29, 2022, the Food and Drug Administration (FDA) authorized a second mRNA booster dose ≥4 months after receipt of a first booster dose for adults aged ≥50 years and persons aged ≥12 years with moderate to severe immunocompromise ( 1, 2).
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